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Endocrine Abstracts

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ea0094oc2.1 | Endocrine Cancer and Late Effects | SFEBES2023

Manipulating NIS endocytosis as a druggable target to enhance radioiodide uptake and prognostic indictor of thyroid cancer recurrence

Read Martin , Brookes Katie , Zha Ling , Manivannan Selvambigai , Kim Jana , Firth George , Sunassee Kavitha , Blower Philip , Boelaert Kristien , Nieto Hannah , Smith Vicki , McCabe Christopher

Background: Diminished sodium iodide symporter (NIS) activity at the plasma membrane (PM) is frequently associated with suboptimal radioiodide (RAI) uptake and poor prognosis in differentiated thyroid cancer (DTC). Endocytosis is a key determinant of symporter activity, with our recent study demonstrating specific interaction of NIS with Adaptor Protein 2 (AP2) – a central player in endocytosis. Here, our objective was to determine whether NIS endocytosis...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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